Rac1/cdc42

BT-AP12225

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized phosho peptide around human Rac1 (Ser71)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is a small GTPase of the Rho-subfamily| which regulates signaling pathways that control diverse cellular functions including cell morphology| migration| endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42| and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP)| which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3| 4| 5| 7| 8 and 20.

Human: P60953; Mouse: P60766; Rat: Q8CFN2;

Human: 998; Mouse: 12540; Rat: 64465

Rac1/cdc42 ;Ser71; Cell division control protein 42 homolog; G25K GTP-binding protein

Signal transduction; Immunology; Cancer