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Home > Product > Antibody > Rad17(Phospho Ser645) Polyclonal Antibody

Rad17(Phospho Ser645) Polyclonal Antibody

Rad17(Phospho Ser645) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: WB, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ELISA

Product overview

Full product name

Cell cycle checkpoint protein RAD17

Code

BT-AP13500

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human RAD17 around the phosphorylation site of Ser645. AA range:621-670

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for 1 year

Background

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h

Uniprot accession

Molecular weight

77055

Gene ID

Human: 5884; Mouse: 19356

Synonyms

Cell cycle checkpoint protein RAD17; RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog

Research area

Epigenetics and nuclear signaling

Target protein

RAD17

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
ELISA 1: 5000

Images

Western Blot analysis of various cells using Phospho-Rad17 (S645) Polyclonal Antibody
Western blot analysis of lysates from HeLa cells treated with UV 15', using RAD17 (Phospho-Ser645) Antibody. The lane on the right is blocked with the phospho peptide.

Protocols

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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