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Home > Product > Antibody > Raf-1 Polyclonal Antibody

Raf-1 Polyclonal Antibody

Raf-1 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human

Applications: WB, IHC-p, IF

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-p, IF

Product overview

Full product name

RAF proto-oncogene serine/threonine-protein kinase

Code

BT-AP13537

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

Recombinant Protein of Raf-1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage

-20°C for 1 year

Background

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Uniprot accession

Gene ID

Human: 5894

Synonyms

RAF proto-oncogene serine/threonine-protein kinase; RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1

Research area

Signal transduction; Cancer; Cell biology; Metabolism

Target protein

RAF1

Recommended dilution

Application Dilution
WB 1: 1000 - 1: 2000
IHC 1: 50 - 1: 200

Images

Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma using Raf-1 Polyclonal Antibody.
Western blot analysis of Hela using Raf-1 Polyclonal Antibody. Secondary antibody was diluted at 1:20000

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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