Full product name
Serum response factor
Code
BT-AP14473
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human SRF around the phosphorylation site of Thr159. AA range:126-175
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.
Uniprot accession
Molecular weight
51593
Gene ID
Human: 6722; Mouse: 20807
Synonyms
Serum response factor; SRF; Serum response factor; SRF
Research area
Epigenetics and nuclear signaling; Developmental biology; Stem cells; Cardiovascular
Target protein
SRF
