Full product name
Netrin receptor UNC5D
Code
BT-AP15364
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,Belongs to the unc-5 family.,Contains 1 death domain.,Contains 1 Ig-like (immunoglobulin-like) domain.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 ZU5 domain.,Contains 2 TSP type-1 domains.,subunit:Interacts with the cytoplasmic part of DCC.,
Uniprot accession
Gene ID
Human: 137970
Synonyms
Netrin receptor UNC5D ;Protein unc-5 homolog 4;Protein unc-5 homolog D
Research area
Neuroscience; Cardiovascular
Target protein
UNC5D
