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Product > Antibody > CTCF Monoclonal Antibody
CTCF Monoclonal Antibody
CTCF Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1D11
Host: Mouse
Reactivity:Human, Monkey
Applications: WB
Product Summary
Size:
50μL
Clonality: 1D11
Host: Mouse
Reactivity: Human,Monkey
Applications: WB
Product overview
Code
BT-MCA3983
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1D11
Immunogen
Purified recombinant fragment of human CTCF expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.
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