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Product > Antibody > OLIG2 Monoclonal Antibody
OLIG2 Monoclonal Antibody
OLIG2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1G11
Host: Mouse
Reactivity:Human
Applications: IHC,ICC
Product Summary
Size:
50μL
Clonality: 1G11
Host: Mouse
Reactivity: Human
Applications: IHC,ICC
Product overview
Code
BT-MCA4423
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1G11
Immunogen
Purified recombinant fragment of human OLIG2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
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