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Home >
Product > Antibody > CRTC3 Monoclonal Antibody
CRTC3 Monoclonal Antibody
CRTC3 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5G9
Host: Mouse
Reactivity:Human, Monkey
Applications: WB,IHC,ICC
Product Summary
Size:
50μL
Clonality: 5G9
Host: Mouse
Reactivity: Human,Monkey
Applications: WB,IHC,ICC
Product overview
Code
BT-MCA4191
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5G9
Immunogen
Purified recombinant fragment of human CRTC3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
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