Code
BT-MCA4322
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5C5
Immunogen
Purified recombinant fragment of human ATM expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Uniprot accession
Molecular weight
351kDa
Gene ID
472
Synonyms
AT1;ATA;ATC;ATD;ATE;ATDC;TEL1;TELO1;MGC74674;DKFZp781A0353;ATM
Research area
Epigenetics and Nuclear Signaling
Target protein
ATM
