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Product > Antibody > KLHL22 Monoclonal Antibody
KLHL22 Monoclonal Antibody
KLHL22 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7B10
Host: Mouse
Reactivity:Human
Applications: WB,ICC
Product Summary
Size:
50μL
Clonality: 7B10
Host: Mouse
Reactivity: Human
Applications: WB,ICC
Product overview
Code
BT-MCA4753
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7B10
Immunogen
Purified recombinant fragment of human KLHL22 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophilakelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
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