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Product > Antibody > IHOG Monoclonal Antibody
IHOG Monoclonal Antibody
IHOG Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3G8
Host: Mouse
Reactivity:Drosophila Melanogaster
Applications:
Product Summary
Size:
50μL
Clonality: 3G8
Host: Mouse
Reactivity: Drosophila Melanogaster
Applications:
Product overview
Code
BT-MCA2193
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3G8
Immunogen
Purified recombinant fragment of human IHOG expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
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