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Product > Antibody > MAP2K2 Monoclonal Antibody
MAP2K2 Monoclonal Antibody
MAP2K2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7F5
Host: Mouse
Reactivity:Human, Mouse, Rat
Applications: WB,ICC,FCM
Product Summary
Size:
50μL
Clonality: 7F5
Host: Mouse
Reactivity: Human,Mouse,Rat
Applications: WB,ICC,FCM
Product overview
Code
BT-MCA3313
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7F5
Immunogen
Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
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