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Product > Antibody > AKT1 Monoclonal Antibody
AKT1 Monoclonal Antibody
AKT1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3A3
Host: Mouse
Reactivity:Human, Mouse, Monkey
Applications: WB
Product Summary
Size:
50μL
Clonality: 3A3
Host: Mouse
Reactivity: Human,Mouse,Monkey
Applications: WB
Product overview
Code
BT-MCA3906
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3A3
Immunogen
Purified recombinant fragment of human AKT1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
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