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Product > Antibody > FGFR1 Monoclonal Antibody
FGFR1 Monoclonal Antibody
FGFR1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3D4F7
Host: Mouse
Reactivity:Human
Applications:
Product Summary
Size:
50μL
Clonality: 3D4F7
Host: Mouse
Reactivity: Human
Applications:
Product overview
Code
BT-MCA2573
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
3D4F7
Immunogen
Purified recombinant extracellular fragment of human FGFR1 (aa22-376) fused with hIgGFc tag expressed in HEK293 cells.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome. It is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.
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