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Product > Antibody > PEG10 Monoclonal Antibody
PEG10 Monoclonal Antibody
PEG10 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4C10A7
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 4C10A7
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA3493
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4C10A7
Immunogen
Purified recombinant fragment of human PEG10 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
PEG10, paternally expressed 10. The PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
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