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Product > Antibody > CHK1 Monoclonal Antibody
CHK1 Monoclonal Antibody
CHK1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2G1D5
Host: Mouse
Reactivity:Human, Mouse
Applications: WB
Product Summary
Size:
50μL
Clonality: 2G1D5
Host: Mouse
Reactivity: Human,Mouse
Applications: WB
Product overview
Code
BT-MCA3955
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2G1D5
Immunogen
Purified recombinant fragment of CHK1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.
We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.
