BT-MCA3151

Mouse

Mouse IgG1

50μL

7H10B9

Purified recombinant fragment of human NPM (2-265) expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

Store at 4°C short term. Aliquot and store at -20°C long term.

Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

P06748: ;

33kDa

4869

B23;NPM

Others

Nucleophosmin