Code
BT-MCA2363
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4C7H12
Immunogen
Purified recombinant fragment of human S100B (AA: 1-92) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Uniprot accession
Molecular weight
10.7kDa
Synonyms
NEF;S100;S100-B;S100beta
Research area
Cell Biology,Signal Transduction,Epigenetics and Nuclear Signaling,Stem Cells
Target protein
S100B
