ATM Monoclonal Antibody

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Blood coagulation
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Home > Product > Antibody > ATM Monoclonal Antibody

ATM Monoclonal Antibody

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity:Human, Mouse, Monkey, Rat

Applications: IHC,ICC,FCM

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity: Human,Mouse,Monkey,Rat

Applications: IHC,ICC,FCM

Product overview

Code

BT-MCA4581

Host

Mouse

Isotype

Mouse IgG2b

Size

100μL,50μL

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

Store at 4°C short term. Aliquot and store at -20°C long term.

Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Uniprot accession

Q13315:;

Molecular weight

350.7kDa

Gene ID

472

Synonyms

AT1;ATA;ATC;ATD;ATE;ATDC;TEL1;TELO1

Research area

Epigenetics and Nuclear Signaling

Target protein

ATM

Recommended dilution

Application	Dilution
IHC-p	1:200 - 1:1000
ICC	1:200 - 1:1000
FCM	1:200 - 1:400
ELISA	1:10000

Images

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using ATM mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Immunofluorescence analysis of NIH/3T3 cells using ATM mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Hela cells using ATM mouse mAb (green) and negative control (red).

Flow cytometric analysis of COS-7 cells using ATM mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded kidney tissues using ATM mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded gastric cancer tissues using ATM mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Mouse spleen tissues using ATM mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Rat myocardium tissues using ATM mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Rabbit spleen tissues using ATM mouse mAb with DAB staining.

Protocols

> Protocol Booklet

Customer reviews and Q&As

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Datasheet

Product size

Price

100μL

$320.00
50μL

$220.00

Add to Cart

Lead time: Within one week

Custom quote | Bulk request

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