SOCS3 Monoclonal Antibody

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Home > Product > Antibody > SOCS3 Monoclonal Antibody

SOCS3 Monoclonal Antibody

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB,IHC,ICC,FCM

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB,IHC,ICC,FCM

Product overview

Code

BT-MCA4370

Host

Mouse

Isotype

Mouse IgG1

Size

100μL,50μL

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human SOCS3 (AA: full(1-225)) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

Store at 4°C short term. Aliquot and store at -20°C long term.

Background

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Uniprot accession

O14543:;

Molecular weight

24.8KDa

Gene ID

9021

Synonyms

CIS3;SSI3;ATOD4;Cish3;SSI-3;SOCS-3

Research area

Signal transduction,Epigenetics and nuclear signaling,Cancer,Stem cells,Metabolism,Immunology

Target protein

SOCS3

Recommended dilution

Application	Dilution
ICC	1:200 - 1:1000
FCM	1:200 - 1:400
ELISA	1:10000

Images

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western blot analysis using SOCS3 mAb against human SOCS3 (AA: full(1-225)) recombinant protein. (Expected MW is 27.7 kDa)

Western blot analysis using SOCS3 mAb against HEK293-6e (1) and SOCS3 (AA:full(1-225))-hIgGFc transfected HEK293-6e (2) cell lysate.

Western blot analysis using SOCS3 mouse mAb against Hela cell lysate.

Immunofluorescence analysis of Hela cells using SOCS3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SOCS3 mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using SOCS3 mouse mAb with DAB staining.

Protocols

> Protocol Booklet

Customer reviews and Q&As

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Datasheet

Product size

Price

100μL

$320.00
50μL

$220.00

Add to Cart

Lead time: Within one week

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