BCL6 Monoclonal Antibody

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Home > Product > Antibody > BCL6 Monoclonal Antibody

BCL6 Monoclonal Antibody

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB,IHC,ICC,FCM

Product Summary

Size: 100μL,50μL

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB,IHC,ICC,FCM

Product overview

Code

BT-MCA3632

Host

Mouse

Isotype

Mouse IgG1

Size

100μL,50μL

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human BCL6 (AA: 507-706) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

Store at 4°C short term. Aliquot and store at -20°C long term.

Background

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Uniprot accession

P41182:;

Molecular weight

78.8KDa

Gene ID

604

Synonyms

BCL5;LAZ3;BCL6A;ZNF51;ZBTB27

Research area

Epigenetics and Nuclear Signaling

Target protein

BCL6

Recommended dilution

Application	Dilution
WB	1:500 - 1:2000
IHC-p	1:200 - 1:1000
ICC	1:200 - 1:1000
FCM	1:200 - 1:400
ELISA	1:10000

Images

Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western blot analysis using BCL6 mAb against human BCL6 (AA: 507-706) recombinant protein. (Expected MW is 26 kDa)

Western blot analysis using BCL6 mAb against HEK293-6e (1) and BCL6 (AA: 507-706)-hIgGFc transfected HEK293-6e (2) cell lysate.

Western blot analysis using BCL6 mouse mAb against Jurkat (1), K562 (2), Raji (3), Ramos (4) and MOLT-4 (5) cell lysate.

Immunofluorescence analysis of Hela cells using BCL6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of HL-60 cells using BCL6 mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using BCL6 mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded cervical carcinoma tissues using BCL6 mouse mAb with DAB staining.

Protocols

> Protocol Booklet

Customer reviews and Q&As

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Datasheet

Product size

Price

100μL

$320.00
50μL

$220.00

Add to Cart

Lead time: Within one week

Custom quote | Bulk request

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