Code
BT-MCA4113
Host
Mouse
Isotype
Mouse IgG2b
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human NR1H2 (AA:1-200) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
Uniprot accession
Molecular weight
51kDa
Gene ID
7376
Synonyms
NER;UNR;LXRB;LXR-b;NER-I;RIP15
Research area
Cardiovascular,Epigenetics and nuclear signaling,Metabolism
Target protein
NR1H2
