Code
BT-MCA3682
Host
Mouse
Isotype
Mouse IgG2a
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human ABCA1 (AA: 2081-2261) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency.
Uniprot accession
Molecular weight
254 kDa
Gene ID
19
Synonyms
TGD;ABC1;CERP;ABC-1;HDLDT1;HPALP1;HDLCQTL13
Research area
Cancer,Cardiovascular,Metabolism,Neuroscience,Signal transduction
Target protein
ABCA1
