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Home > Product > Antibody > Cleaved-Tumstatin (P1426) Polyclonal Antibody

Cleaved-Tumstatin (P1426) Polyclonal Antibody

Cleaved-Tumstatin (P1426) Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Monkey

Applications: WB, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Monkey

Applications: WB, ELISA

Product overview

Full product name

Cleaved-Tumstatin (P1426) Antibody

Code

BT-AP01968

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:1407-1456

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. COL4A3 encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. COL4A3 is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, COL4A3 is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Uniprot accession

Molecular weight

161813

Gene ID

Human: 1285

Synonyms

COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen

Research area

Signal Transduction

Target protein

COL4A3

Recommended dilution

Application Dilution
WB 1: 500 - 1: 2000
ELISA 1: 40000

Images

Western Blot analysis of various cells using Cleaved-Tumstatin (P1426) Polyclonal Antibody
Western blot analysis of lysates from Jurkat and COS7 cells, treated with etoposide 25uM 24h, using Collagen IV alpha3 (Cleaved-Pro1426) Antibody. The lane on the right is blocked with the synthesized peptide.

Protocols

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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