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Home > Product > Antibody > p107 Polyclonal Antibody

p107 Polyclonal Antibody

p107 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse

Applications: IF, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse

Applications: IF, ELISA

Product overview

Full product name

p107 Antibody

Code

BT-AP06734

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from human RBL1. AA range:335-384

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

The protein encoded by RBL1 (RB transcriptional corepressor like 1) is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for RBL1.

Uniprot accession

Molecular weight

120847

Gene ID

Human: 5933; Mouse: 19650

Synonyms

RBL1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1

Research area

Cell Biology

Target protein

RBL1

Recommended dilution

Application Dilution
IF 1: 200 - 1: 1000
ELISA 1: 5000

Images

Immunofluorescence analysis of NIH/3T3 cells, using RBL1 Antibody. The picture on the right is blocked with the synthesized peptide.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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