BT-MCA4755

Mouse

Mouse IgG1

50μL

2H5

Purified recombinant fragment of human SNAI2 expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

Store at 4°C short term. Aliquot and store at -20°C long term.

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in gamma-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

O43623: ;

30kDa

6591

SLUG;WS2D;SLUGH1;MGC10182;SNAI2

Neuroscience,Cancer,Stem cells,Epigenetics and nuclear signaling,Developmental biology

SNAI2