Code
BT-MCA4817
Host
Mouse
Isotype
Mouse IgG1
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human SOCS3 (AA: 1-225) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Uniprot accession
Molecular weight
24.8KDa
Gene ID
9021
Synonyms
CIS3;SSI3;ATOD4;Cish3;SSI-3;SOCS-3
Research area
Signal transduction,Epigenetics and nuclear signaling,Cancer,Stem cells,Metabolism,Immunology
Target protein
SOCS3
